Tarsis Brust Fernandes

O foco da minha pesquisa é a farmacologia de receptores acoplados a proteína G (GPCR) e adenilado ciclase. Durante o meu doutorado em Purdue University sob a orientação do Dr. Val Watts, meus projetos foram centrados na seletividade funcional de drogas que agem no receptor dopaminérgico D2 e na identificação de inibidores de adenilado ciclase tipo 1. Atualmente atuo como pós-doc no The Scripps Research Institute sob a orientação da Dr. Laura Bohn pesquisando novas drogas que agem no receptor kappa opioide.

The primary focus of my research has been the molecular pharmacology of G protein-coupled receptors (GPCRs) and adenylyl cyclases. The main projects of my doctoral work under the supervision of Dr. Val Watts at Purdue University comprised functional selectivity of ligands at the dopamine D2 receptor and the identification of novel classes of inhibitors of type 1 adenylyl cyclase. These experiences led to a strong background in cell culture, pharmacological assay design, and cell imaging. Now as a postdoctoral research associate at The Scripps Research Institute under the supervision of Dr. Laura Bohn my focus has been on biased ligands at the kappa opioid receptor. In addition to employing my previous molecular pharmacology expertize, my work and skillset now include pre-clinical mouse models.