Sílvia Regina Cavani Jorge Santos

Academic Life in the School of Pharmaceutical Sciences Professor (full) Chair Clinical Pharmacokinetics - Pharmacotherapy - Clinical Trials (2001) Privat Dozent (1988), Associate Professor (1988). National Council of Research (CNPq) Group Lieder "Clinical Pharmacokinetics" since 1990. Academical studies Pharmacist-Biochemist Graduated at School of Pharmaceutical Sciences from University of Sao Paulo (1972) Master of Pharmacy from University of Sao Paulo (1976). Doctoral sandwich grant/Capes in England/ Bradford University (1980-1981). Doctor of Pharmacy_Toxicology from University of Sao Paulo (1982). Post doctoral studies in Germany and in The Netherlands (1986-1994). Expertize in Clinical Pharmacokinetics_ Clinical trials _ Bioanalytical analyses related to the following subjects: Therapeutic Drug Monitoring (TDM), Pharmacokinetics, PK/PD modeling, PK/PD approach to combat the microbial resistance in critically ill ICU patients with fungal and bacterial infections caused by nosocomial pathogens.

Academic title: Graduated in Pharmacy-Biochemistry from the University of São Paulo (1972), Postgraduate from the University of São Paulo in Toxicology and Toxicological Analysis (Master's, 1976), and Toxicology (Doctorate, 1982). She completed a sandwich doctorate at the University of Bradford, Bradford, England (CAPES scholarship, period 1980-1981). She carried out postdoctoral internships abroad at the University of Essen, Kiel, Dresden in Germany (1986-1992) and at the University of Leiden & LACDR (Holland). She served as technical director of a specialized service at the Laboratory of Therapeutic Drug Monitoring, Instituto do Coração HC FMUSP (1977-2004). As a professor at the University of São Paulo, she taught undergraduate and graduate courses (Pharmacotherapy, Basic Pharmacokinetics, Applied Clinical Pharmacokinetics and Advanced Pharmacokinetics). Titled 39 masters and doctors in the period (1988 to 2023). Experienced researcher and leadership in drug transfer studies, with emphasis on pharmacokinetic and pharmacodynamic modeling, study of interaction and genetic polymorphism by CYP marker drugs. Investigator with experience in controlled clinical trials conducted in critically ill patients in intensive care, at the last 20 years in major burns. She has leadership with undergraduate and graduate students, healthcare professionals in hospitals. She is the lead researcher of the "Clinical Pharmacokinetics" Group of the CNPq Research Groups Board, with 47 researchers (plastic surgeons, intensive care physicians, clinical pharmacists, biochemists, biologists and biomedical doctors), including graduate students from Graduate Programs in "Anesthesiology, Surgical Sciences and Perioperative Medicine" from the Faculty of Medicine of the University of Sao Paolo. SP, Brazil She currently teaches PK/PD courses at the hospital, and is also a collaborating researcher in the thematic area "Microbial Resistance" at the Division of Plastic Surgery and Burns, Department of Surgery, and at the Biochemical-Toxicology of Central Laboratory, Department of Clinical Pathology, Faculty of Medicine, University of São Paulo. At the moment, the researcher group are investigating biotransporters involved in the renal excretion of beta-lactam agents (OAT1, OAT3, MRP4). Additionally, two new biomarkers of systemic inflammatory response syndrome in septic shock (IL6 and PCT) are being investigated in critically ill patients in ICU. The group's researcher is investigating new strategies related to dose regimen, duration of infusion, and new therapeutic targets by applying the "Pharmacokinetic-Pharmacodynamic (PK/PD) tools" in order to guarantee the effectiveness-safety of antimicrobial and antifungal agents through of clinical and microbiological healing. All study protocols (approved by CONEPE-MS after referral to CAPPESQ, CEP of the hospital) are carried out in critical septic patients/bedside to combat the development of resistance, consequently aiming at reducing deaths in ICUs, mainly resulting from emergence by MDR".