Mohamed Ahmed Mohamed Hamed Abdelsalam

I have obtained my PhD in Pharmaceutical Sciences from the School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo/in a Joint Collaboration with Mayo Clinic School of Medicine, Department of Internal Medicine, MN, United States. My PhD thesis was entitled: Synthesis, antiurolithic activity and biotransformation studies of galloylquinic acids from Copaifera species by filamentous fungi. I have got my Master's (2012) and Bachelor Degrees (2008) in Pharmaceutical Sciences from the Faculty of Pharmacy, University of Alexandria, Egypt. My Master's thesis was entitled: Cytotoxicity, antiviral and tissue culture-based biotransformation study of Berberis vulgaris (L.). I am currently working as a Lecturer of Pharmacognosy at Faculty of Pharmacy, Delta University for Science and Technology, Egypt. I worked as Teaching Assistant at the Department of Pharmaceutical Organic Chemistry (2008-2010). Research Assistant at Cell Culture Unit, Medical Research Institute, University of Alexandria University (2010-2012), during which I was a part of the team of the research project entitled: Efficient anti-HCV vaccine with protein-transduced dendritic cells, Project No. 1557, STDF, Egypt. My overarching research interests revolve around the discovery of new biological molecules as potential drug leads/candidates based on natural products (microbial and medicinal plants secondary metabolites). I perform biological and pharmacological screenings of bioactive isolated and/or semi-synthesized compounds. I use a combination of Pharmaceutical Chemistry and Modern Chemical biology techniques to answer the how, who, where and how fast questions of natural organic molecules as potential entities in drug discovery. More specifically, I am interested in answering biological questions by directly probing living systems at the chemical level as well as examining the direct and intimate relationship between the activity of semi-synthesized plant secondary metabolites, filamentous fungi-transformed molecules and how that signature may translate between generating library of new drug candidates and their structure-activity relationship (SAR). Moreover, the use of cell bioreactors at the meeting point between engineered and biological chemical synthesis. The biological assays I am using involve in vitro and ex vivo cell culture models, molecular biology, cytotoxicity as well as in vivo Drosophila models. My PhD research work included three parts: total synthesis of a bioactive polyphenolic compound; antiurolithic assays based on identifying Calcium oxalate monohydrate-binding proteins of renal cells and their inhibition, Drosophila ex vivo and in vivo crystallization models, ROS scavenging activity; biotransformation of polyphenolics by filamentous fungi. My Master research involved: antiviral, antitumor and biotransformations studies using plant cell culture. I picked up an International Prize of BIOVISION Next/TWAS/Université de Lyon/Pulsalys SATT Lyon St-Etienne, 2015, Lyon, France, in recognition of the most innovative Ph.D. project and its contribution towards life sciences.

graduation at Pharmaceutical Sciences from Alexandria University (2008), master's at Pharmaceutical Sciences from Alexandria University (2012) and doctorate at Programa de Pós-Graduação em Ciências Farmacêuticas from Universidade de São Paulo (2018). Has experience in Pharmacy, focusing on Pharmacognosy