Síntese de Substâncias Bioativas Conceito

área de pesquisa

• 2-Arylydene Indan-1,3-Diones as Promising Candidates to Inhibit Bacterial Biofilm Formation
• Antiviral activity of Cenostigma pluviosum var. peltophoroides extract and fractions against SARS-CoV-2
• Association of electroanalytical and spectrophotometric methods to evaluate the antioxidant activity of isobenzofuranone in primary cultures of hippocampal neurons
• Combined SRPK and AKT pharmacological inhibition is synergistic in T-cell acute lymphoblastic leukemia cells
• Derivados 1,2,3-triazólicos da ftalimida e trifluorometilarilamidas: síntese e avaliações de atividades citotóxica, fungicida e contra microalgas e cianobactéricas
• Desenvolvimento de uma rota sintética para a obtenção de novos derivados da vanilina com fragmentos 1,2,3-triazólicos e avaliação da atividade leishmanicida
• Effect of the topical administration of N-(2-(4-bromophenylamino)-5-(trifluoromethyl)phenyl)nicotinamide compound in a murine subcutaneous melanoma model
• Eugenol derivatives with 1,2,3-triazole moieties: Oral treatment of cutaneous leishmaniasis and a quantitative structure-activity relationship model for their leishmanicidal activity
• Evaluation of Antiviral Activity of Cyclic Ketones against Mayaro Virus
• First evidence of a serine arginine protein kinase (SRPK) in leishmania braziliensis and its potential as therapeutic target
• Immunomodulatory activity of trifluoromethyl arylamides derived from the SRPK inhibitor SRPIN340 and their potential use as vaccine adjuvant
• In vitro evaluation of antileishmanial activity, mode of action and cellular response induced by vanillin synthetic derivatives against Leishmania species able to cause cutaneous and visceral leishmaniasis
• In vitro tripanocidal effect of 1,8-dioxooctahydroxanthenes (xanthenodiones) and tetraketones and improvement of cardiac parameters in vivo
• Isobenzofuran-1(3H)-ones as new tyrosinase inhibitors: Biological activity and interaction studies by molecular docking and NMR
• Methoxylated Cinnamic Esters with Antiproliferative and Antimetastatic Effects on Human Lung Adenocarcinoma Cells
• Neuroprotective Effect of Isobenzofuranones on Hydrogen Peroxide-Mediated Redox Imbalance in Primary Cultures of Hippocampal Neurons
• Química Medicinal de Produtos Sintéticos e Naturais
• Rosângela Bezerra da Silva
• Structure-based discovery of thiosemicarbazones as SARS-CoV-2 main protease inhibitors
• Synthesis and Evaluation of the Antileishmanial Activity of Novel Eugenol Analogs Containing 1,2,3-Triazole Fragments Against Intracellular Leishmania braziliensis
• Synthesis and Fungicide Activity on of Glycerol Derivatives Bearing 1,2,3-Triazole Fragments
• Synthesis and virucide activity on zika virus of 1,2,3-triazole-containing vanillin derivatives
• Synthesis of 1,2,3-Triazole Benzophenone Derivatives and Evaluation of in vitro Sun Protection, Antioxidant Properties, and Antiproliferative Activity on HT-144 Melanoma Cells
• Synthesis of 1,2,3-Triazole-Containing Methoxylated Cinnamides and Their Antileishmanial Activity against the Leishmania braziliensis Species
• Synthesis of cinnamic acid ester derivatives with antiproliferative and antimetastatic activities on murine melanoma cells
• Synthesis of eugenol-fluorinated triazole derivatives and evaluation of their fungicidal activity
• SYNTHESIS OF GLYCEROL-FLUORINATED TRIAZOLE DERIVATIVES AND EVALUATION OF THEIR FUNGICIDAL ACTIVITY
• Synthesis of Novel Cinnamides and a Bis Cinnamate Bearing 1,2,3-Triazole Functionalities with Antiproliferative and Antimetastatic Activities on Melanoma Cells
• Synthesis of novel glycerol-fluorinated triazole derivatives and evaluation of their phytotoxic and cytogenotoxic activities
• Synthesis of vanillin derivatives with 1,2,3-triazole fragments and evaluation of their fungicide and fungistatic activities
• Synthesis, biological activity, and four-dimensional quantitative structure?activity analysis of 2- arylidene indan-1,3-dione derivatives tested against Daphnia magna
• Síntese de 2-arilideno indan-1,3-dionas contendo porções triazólicas e avaliação de suas atividades citotóxica e fotoprotetora
• SÍNTESE DE 2-ARILIDENO INDAN-1,3-DIONAS E AVALIAÇÃO DAS ATIVIDADES ANTIVIRAL, CITOTÓXICA E LEISHMANICIDA
• SÍNTESE DE DERIVADOS DA VANILINA CONTENDO O NÚCLEO 1,2,3-TRIAZÓLICO E AVALIAÇÃO DAS ATIVIDADES LEISHMANICIDA, CITOTÓXICA, FUNGICIDA E INSETICIDA E OBTENÇÃO DE NOVOS DERIVADOS 1,2,3-TRIAZÓLICOS DO EUGENOL
• Síntese de derivados do ácido cinâmico e avaliação das atividades leishmanicida e antitumoral
• Síntese de isobenzofuranonas e indan-1,3-dionas: aspectos estruturais e avaliação das atividades citotóxica, leishmanicida e inibitória da protease NS2B-NS3 do West Nile Virus (WNV)
• SÍNTESE DE NOVOS 1,2,3-TRIAZÓIS INSPIRADOS NO SRPIN 340 E AVALIAÇÃO DE ATIVIDADES ANTIPARASITÁRIA E ANTITUMORAL
• SÍNTESE DE NOVOS DERIVADOS DO EUGENOL CONTENDO FRAGMENTOS 1,2,3-TRIAZÓLICOS E AVALIAÇÃO DE SUAS ATIVIDADES FUNGICIDA E ANTIVIRAL
• Síntese e AVALIAÇÃO DAS ATIVIDADES FITOTÓXICA E CITOTÓXICA DE 3-(2-ARIL-2-OXOETIL)-ISOBENZOFURAN-1(3H)-ONAS
• Síntese e avaliação da atividade citotóxica de ésteres derivados dos ácidos 4-metoxi cinâmico e 3,4-dimetoxicinâmico frente à linhagem de melanoma SKMEL-147
• SÍNTESE E AVALIAÇÃO DA ATIVIDADE CITOTÓXICA E DO EFEITO SOBRE O TRANSPORTE FOTOSSINTÉTICO DE ELÉTRONS DE TRIFLUOROMETIL-ARIL-AMIDAS
• Síntese e avaliação das atividades citotóxica e antiviral de derivados do SRPIN 340 contendo fragmentos 1,2,3-triazólicos
• Síntese e Avaliação das Atividades Citotóxica e Leishmanicida de Cinamatos Derivados da Vanilina
• SÍNTESE E AVALIAÇÃO DAS ATIVIDADES CITOTÓXICA, INSETICIDA E LEISHMANICIDA DE NOVOS ANÁLOGOS AO EUGENOL CONTENDO NÚCLEOS 1,2,3-TRIAZÓLICOS
• The SRPK inhibitor N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl) isonicotinamide (SRPIN340) increases the immune response against metastatic melanoma in mice
• Vibrational spectroscopic studies, theoretical aspects, and X-ray analysis of xanthenodiones (1,8-dioxooctahydroxanthenes)
• XANTENODIONAS: SÍNTESE, ASPECTOS TEÓRICOS E ESTRUTURAIS E AVALIAÇÃO DAS ATIVIDADES FUNGICIDA E LEISHMANICIDA
• Xanthenedione (and intermediates involved in their synthesis) inhibit Zika virus migration to the central nervous system in murine neonatal models