Several molecules that are produced in peripheral organs may achieve central nervous system, thus modulating plenty of peripheral and central functions. Either by crossing blood brain barrier or by achieving central nervous system through regions with high permeability (such as hypothalamus), these molecules may modify the activity of central pathways controlling behaviour, neuroendocrine and autonomic functions. In these regards, our lab dedicates to neuroscientific studies with integrative aims, which may serve a better understanding on several functions orchestrated by central nervous system. We study neural pathways, neurochemical aspects, behavioral-autonomic interfaces, central effects of peripheral hormones and pathophysiology of diseases that involve central components.