membro de NEQUIMA - Núcleo de Estudos Químicos de Micromoléculas da Amazônia Grupo de Pesquisa Oncologia Experimental e Clínica Grupo de Pesquisa Tecnologia Química-Farmacêutica & Inovação Terapêutica Grupo de Pesquisa
publicações selecionadas Asperelines Produced by the Endophytic Fungus Trichoderma asperelloides From the Aquatic Plant Victoria amazonica Physicochemical Characterization, Stability and Cytotoxicity of a Blue Dye Obtained from Genipap (Genipa americana L.) Fruit Ocotea(Lauraceae) Amazonian essential oils chemical composition and their tyrosinase inhibition to use in cosmetics Potencial dos análogos do dilapiol para uso em Doenças Negligenciadas, com ênfase para Leishmaniose Cutânea: revisão literária / Potential of dilapiol analogues for use in Neglected Diseases, with emphasis on Cutaneous Leishmaniasis: a literature review Hypoglycemic effect of the dry leaf extract of Myrcia multiflora in streptozotocin-induced diabetic mice Antimicrobial Potential of Metabolites in Fungal Strains Isolated from a Polluted Stream: Annulohypoxylon stygium WL1B5 Produces Metabolites against Extended-Spectrum Beta-Lactamase-Positive Escherichia coli Cytotoxicity and Lipase Inhibition of Essential Oils from Amazon Annonaceae Species CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITIES OF THE LEAF EXTRACT AND ESSENTIAL OIL FROM Piper alatabaccum (Piperaceae) FRUITS. qNMR quantification of phenolic compounds in dry extract of Myrcia multiflora leaves and its antioxidant, anti-AGE, and enzymatic inhibition activities The selective obtaining of amyrins from Amazonian Protium oleoresins Antimicrobial and cytotoxic activity of fungal mycelial extracts from aquatic environments in the Amazon Hypoglycemic effect and toxicity of the dry extract of Eugenia biflora (L.) DC. leaves Essential Oil from Bark of Aniba parviflora ( Meisn .) Mez (Lauraceae) Reduces HepG2 Cell Proliferation and Inhibits Tumor Development in a Xenograft Model Semisynthetic triterpenes led to the generation of selective antitrypanosomal lead compounds 22β-hydroxytingenone induces apoptosis and suppresses invasiveness of melanoma cells by inhibiting MMP-9 activity and MAPK signaling 22β-hydroxytingenone reduces proliferation and invasion of human melanoma cells Silver tungstate microcrystals and their performance over several clinical multidrug resistant microorganisms ATIVIDADES ANTIOXIDANTE E ANTIBACTERIANA in vitroDE EXTRATOS VEGETAIS DA FAMÍLIA ANNONACEAE QUANTIFICATION OF BERGENIN, ANTIOXIDANT ACTIVITY AND NITRIC OXIDE INHIBITION FROM BARK, LEAF AND TWIG OF Endopleura uchi Optimization of Phenolic Extraction from Bacuri (Platonia insignis Mart.) Shells Using Response Surface Methodology Propiedades antiinflamatorias y antioxidantes del extracto de corteza de Bertholletia excelsa (H.B.K) Neuroprotective and anti-inflammatory effect of pectolinarigenin, a flavonoid from Amazonian Aegiphila integrifolia (Jacq.), against lipopolysaccharide-induced inflammation in astrocytes via NFκB and MAPK pathways Antioxidant effect of Hymenaea Courbaril L (Jatobá) sap on the healing of wounds on mice Physsicochemical characterization and cosmetic applications of Passiflora nitida Kunth leaf extract Amazonian Melastomataceae blueberries: Determination of phenolic content, nutritional composition, and antioxidant and anti-glycation activities Comparative evaluation of the chemical composition and biological activities of tropical fruits consumed in Manaus, central Amazonia, Brazil A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways
theses/dissertations advising ESTUDO COMPARATIVO ENTRE TÉCNICAS PARA AVALIAÇÃO DE ATIVIDADES ANTIOXIDANTES DE ESPÉCIES DE PLANTAS DA AMAZÔNIA SÍNTESE, CARACTERIZAÇÃO QUÍMICA E ATIVIDADES BIOLÓGICAS DE UM NOVO DERIVADO DA NARINGENINA Obtenção da mistura triterpenica de alfa e beta-amirenona e avaliação de seus efeitos hipolipemiante, hipoglicemiante e antiobesidade. Atividade antileishmania de um derivado do dilapiol obtido a partir de Piper aduncum L. (Piperaceae) Avaliação da atividade anti-inflamatória de compostos triterpênicos isolados de óleo resina de Protium paniculatum Uma nova chalcona com atividade antidiabética Efeito antineoplásico de uma nova naftoquinona sintetizada a partir da Lausona Avaliação da atividade antidiabética de extratos das cascas de Salacia impressifolia Estudo químico e farmacológico do gênero Byrsonima visando o desenvolvimento de novos anti-inflamatórios e antimicrobianos Marcadores de estresse oxidativo em plasma e eritrócitos de pacientes com malária vivax grave Relação entre o Estresse Oxidativo e a Plaquetimetria de Pacientes com Malária Vivax Biotransformação de quercetina por Penicillium isolado de Gustavia elliptica S.A. Mori (Lecythidaceae)