Christophe Olivier SOULAGE

Currículo curto em português:// Possuo um doutorado em fisiologia integrada da Universidade Claude Bernard Lyon 1 (2004, Lyon, França) e uma acreditação para dirigir pesquisas (2014, INSA-Lyon, França). Atualmente, eu sou Professor titular (Full) na Universidade Claude Bernard Lyon 1 em Lyon (França). Estou designado por meus cursos e minhas pesquisas para os departamentos de ?Biociências? e ?Medicina?. A minha principal área de investigação é a nefrologia com particular interesse na doença renal crónica e na tocinas urémicas. Sou autor de mais de 80 publicações científicas em fisiologia, endocrinologia e nefrologia. // // Resume in English: // I received my Ph.D. degree in Integrative Physiology from the University Claude Bernard of Lyon (France) in 2004. In 2005, after one year of post doctorate, I was appointed as an Associate Professor of Physiology and Pharmacology at the French elite school INSA-Lyon. In 2019, I was appointed as Full Professor of Physiology in Université Claude Bernard Lyon 1 (Lyon, France) affected to both the Departments of Medicine and BioSciences. I have been, since 2011, Principal Investigator at the laboratory INSERM U1060 CarMeN (CarMeN lab standing for Cardiovascular, metabolism, diabetes, and nutrition) in Lyon. My first research interests were focused on the pathophysiological mechanisms underlying the development of insulin resistance and metabolic syndrome. Insulin resistance is indeed a primary risk factor for several common diseases, including diabetes, cardiovascular diseases, and hypertension. I was especially interested in the role of oxidative stress and especially lipid peroxidation by products in the pathogenesis of insulin resistance and type 2 diabetes. My current research interests are focused on the cardio-metabolic consequences of uremia. Chronic kidney disease (CKD) is characterized by several profound alterations in metabolism, among which dyslipidemia and insulin resistance that contribute to the increased cardiovascular risk observed in these patients. My current research effort consists of understanding the role of compounds named uremic toxins, accumulated because of decreased renal clearance, in the development of cardio-metabolic disturbances associated with CKD. I am involved in a trully translational research ranging from in vitro (cell culture), animal experiments (animal models of metabolic disease or kidney failure) to clinical studies performed in collaboration with the Lyon University hospital (Department of Nephrology). I am the author of more than 80 scientific publications in the fields of physiology, endocrinology and nephrology (H-factor 29 in early 2022).